Shekoni is most well known for playing the role of Precious Hudson in the British soap EastEnders in 2002. She has also appeared in films including Garfield 2, Jekyll and Hyde, and Ali G Indahouse. Shekoni has also made guest appearances in Casualty, Fat Friends and The King of Queens. In 2005, she appeared in the ITV reality TV show, Love Island.
She currently resides in Los Angeles, California where she has appeared on US television shows such as NCIS, All of Us and Damages. She is the host of Fox Reality show When Women Rule the World, which is yet to air. She has been cast as Zafrina in the film Breaking Dawn.
Shekoni, along with British Supermodel Amanda Van Annan, is the founder of Extension Evolution, a company supplying premium hair extensions and is also the founder of two other companies, Make It America and Actors Evolution.